Genotype—environment interactions and the estimation of the genomic mutation rate in Drosophila melanogaster
1994; Royal Society; Volume: 258; Issue: 1353 Linguagem: Inglês
10.1098/rspb.1994.0166
ISSN1471-2954
AutoresAlexey S. Kondrashov, David Houle,
Tópico(s)Insect-Plant Interactions and Control
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Kondrashov Alexey S. and Houle David 1994Genotype—environment interactions and the estimation of the genomic mutation rate in Drosophila melanogasterProc. R. Soc. Lond. B.258221–227http://doi.org/10.1098/rspb.1994.0166SectionRestricted accessArticleGenotype—environment interactions and the estimation of the genomic mutation rate in Drosophila melanogaster Alexey S. Kondrashov Google Scholar Find this author on PubMed Search for more papers by this author and David Houle Google Scholar Find this author on PubMed Search for more papers by this author Alexey S. Kondrashov Google Scholar Find this author on PubMed and David Houle Google Scholar Find this author on PubMed Published:22 December 1994https://doi.org/10.1098/rspb.1994.0166AbstractWe have studied the relative fitnesses of three genotypes of Drosophila melanogaster in 50 environments. Two genotypes, the MA lines, had accumulated mutations in the absence of natural selection over 62 generations. The third was a related strain where selection had continued to act. The environments differed in three factors: parental density, dilution of the medium, and the temperature régime and medium composition. Our measure of fitness assessed fecundity and viability relative to a reference genotype. Both MA lines always had lower fitnesses than the selected line, but the difference increased dramatically with dilution of the medium and, especially, crowding. Under the most severe conditions, the performance of the MA lines approached 0. This increased difference in harsh conditions may be caused both by a uniform increase in the magnitude of deleterious effects of all mutations and by the exposure of mutations which are essentially neutral under benign conditions. If the second cause is important, previous experiments are likely to have underestimated the genomic deleterious mutation rate in Drosophila melanogaster more than previously thought.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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