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Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

2012; Elsevier BV; Volume: 12; Issue: 11 Linguagem: Inglês

10.1016/s1473-3099(12)70181-0

1474-4457

Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Erika S Phelps, Kasia Stepniewska, Pharath Lim, Chong-Jun Zhou, Sivanna Mao, Jennifer M. Anderson, Niklas Lindegårdh, Hongying Jiang, Jianping Song, Xin‐zhuan Su, Nicholas J. White, Arjen M. Dondorp, Tim Anderson, Michael P. Fay, Jianbing Mu, Duong Socheat, Rick M. Fairhurst,

Trypanosoma species research and implications

Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this phenotype in western Thailand and possibly elsewhere threatens to compromise the effectiveness of all artemisinin-based combination therapies. Parasite genetics is associated with parasite clearance rate but does not account for all variation. We investigated contributions of both parasite genetics and host factors to the artemisinin-resistance phenotype in Pursat, western Cambodia.