Bioanalytical application of surface‐ and tip‐enhanced R aman spectroscopy
2012; Wiley; Volume: 12; Issue: 2 Linguagem: Inglês
10.1002/elsc.201100056
ISSN1618-2863
AutoresSusanne Pahlow, Anne März, Barbara Seise, Katharina Hartmann, Isabel Freitag, Evelyn Kämmer, René Böhme, Volker Deckert, Karina Weber, Dana Cialla‐May, Jürgen Popp,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoDue to its fingerprint specificity and trace‐level sensitivity, surface‐enhanced R aman spectroscopy ( SERS ) is an attractive tool in bioanalytics. This review reflects the research in this highly interesting topic of the last 3–4 years. The detection of the SERS signature of biomolecules up to microorganisms and cells is introduced. Labeling using modified nanoparticles ( SERS tags) is also introduced. In order to establish biomedical applications, SERS analysis is performed in complex matrices such as body fluids. Furthermore, the SERS technique is combined with other methods such as microfluidic devices for online monitoring and scanning probe microscopy (i.e. tip‐enhanced R aman spectroscopy, TERS) to investigate nanoscaled features. The present review illustrates the broad application fields of SERS and TERS in bioanalytics and shows the great potential of these methods for biomedical diagnostics.
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