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Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

2011; Elsevier BV; Volume: 12; Issue: 1 Linguagem: Inglês

10.1016/j.mito.2011.07.004

1872-8278

Carlotta Giorgi, Chiara Agnoletto, Angela Bononi, Massimo Bonora, Elena De Marchi, Saverio Marchi, Sonia Missiroli, Simone Patergnani, Federica Poletti, Alessandro Rimessi, Jan M. Suski, Mariusz R. Wiȩckowski, Paolo Pinton,

Metabolism and Genetic Disorders

Mitochondria are crucial in different intracellular pathways of signal transduction. Mitochondria are capable of decoding a variety of extracellular stimuli into markedly different intracellular actions, ranging from energy production to cell death. The fine modulation of mitochondrial calcium (Ca(2+)) homeostasis plays a fundamental role in many of the processes involving this organelle. When mitochondrial Ca(2+) homeostasis is compromised, different pathological conditions can occur, depending on the cell type involved. Recent data have shed light on the molecular identity of the main proteins involved in the handling of mitochondrial Ca(2+) traffic, opening fascinating and ambitious new avenues for mitochondria-based pharmacological strategies.