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Toxoplasma Gondii in an African Crested Porcupine ( Hystrix Cristata)

2007; SAGE Publishing; Volume: 19; Issue: 2 Linguagem: Inglês

10.1177/104063870701900210

1943-4936

Tara M. Harrison, Jamee Black Moorman, Steven R. Bolin, Nicole L. Grosjean, Ailam Lim, Scott D. Fitzgerald,

Rabies epidemiology and control

An adult female crested porcupine (Hystrix cristata) was evaluated for acute onset of neurologic signs including head tilt, circling, and ataxia. She was found dead in her holding area 2 days after initially exhibiting clinical signs. Necropsy was unremarkable. Histopathology of brain tissue revealed the presence of protozoal cysts associated with inflammation as the underlying cause of clinical signs and death. Immunohistochemical staining of brain tissue for Toxoplasma gondii was strongly positive. PCR on fresh brain confirmed T. gondii as the causative organism. An adult male in the same enclosure has demonstrated similar neurologic signs over the past 3 years and has failed to respond to various medical treatments. Clinical disease associated with T. gondii has not been previously reported in this porcupine species or any other Old World porcupines, although there are several reports of clinical toxoplasmosis involving New World porcupine species.