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Immunization against Influenza: Comparison of Various Topical and Parenteral Regimens Containing Inactivated and/or Live Attenuated Vaccines in Healthy Adults

2001; Oxford University Press; Volume: 183; Issue: 2 Linguagem: Inglês

10.1086/317926

1537-6613

Wendy A. Keitel, Thomas R. Cate, Diane Niño, Linda L. Huggins, Howard R. Six, John M. Quarles, Robert B. Couch,

Respiratory viral infections research

Methods for enhancing immune responses to influenza were explored in 2 double-blind, placebo-controlled trials. Intranasal (in1) immunization with monovalent, live attenuated, cold-adapted recombinant (CR) or inactivated influenza virus (MIV) vaccine and intramuscular (im) immunization with MIV were evaluated in various combinations. Healthy susceptible adults were assigned randomly to receive 107.1 TCID50 of CR (A/H1N1 or A/H3N2), homologous MIV (15 µg), or placebo inl and placebo or homologous MIV im (6 groups in each study). Serum antibody responses were greatest in groups given im vaccine (with or without inl vaccine). A 2-fold increase in nasal wash antibody response frequencies was seen in groups given combined inl (CR or MIV) and im vaccine, compared with subjects given a single im (MIV) or inl (CR or MIV) vaccine. Combined in1 and im immunization is a promising approach for enhancing both local and systemic immune responses against influenza.