Friedel–Crafts reaction of indoles with N-silyl-N,O-acetal catalyzed by Cu(OTf)2 in the presence of TMSCl leading to indolyl primary amines
2002; Elsevier BV; Volume: 43; Issue: 27 Linguagem: Inglês
10.1016/s0040-4039(02)00921-8
ISSN1873-3581
AutoresNorio Sakai, Toshihiro Hamajima, Takeo Konakahara,
Tópico(s)Chemical Synthesis and Analysis
ResumoA catalytic amount of copper(II) trifluoromethanesulfonate (Cu(OTf)2) in the presence of trimethylchlorosilane (TMSCl) effectively promoted the aminomethylation of indoles bearing a variety of functional groups with a N-silyl-N,O-acetal in good to excellent yields.
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