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The DAPIN family: a novel domain links apoptotic and interferon response proteins

2001; Elsevier BV; Volume: 26; Issue: 2 Linguagem: Inglês

10.1016/s0968-0004(00)01717-5

1362-4326

Eike Staub, Edgar Dahl, André Rosenthal,

Cell death mechanisms and regulation

We report the discovery of a protein domain, hereafter referred to as DAPIN, in diverse vertebrate and viral proteins that is associated with tumor biology, apoptosis and inflammation. Based on a secondary structure prediction, we suggest an all-alpha fold for DAPIN, which is also adopted by apoptotic protein domains of the CARD, death domain and death effector domain type.