Portal de Periódicos da CAPES

Oral amphipathic peptides as therapeutic agents

2005; Taylor & Francis; Volume: 15; Issue: 1 Linguagem: Inglês

10.1517/13543784.15.1.13

1744-7658

Srinivasa T. Reddy, G.M. Anantharamaiah, Mohamad Navab, Susan Hama, G P Hough, Víctor Grijalva, David W. Garber, Geeta Datta, Alan M. Fogelman,

Curcumin's Biomedical Applications

Cholesterol can promote inflammation by its ability to stimulate the production of reactive oxygen species that result in the formation of pro-inflammatory oxidised phospholipids. High-density lipoproteins (HDLs) are part of the innate immune response and can be either pro- or anti-inflammatory independently of plasma HDL–cholesterol levels. During systemic inflammation as occurs with atherosclerosis, Apolipoprotein A-I can be altered, reducing its ability to promote reverse cholesterol transport and HDL can become pro-inflammatory. Amphipathic peptides with either a class A amphipathic helix (D-4F) or a class G* amphipathic helix (D-[113-122]apoJ), or even those that are too small to form a helix (KRES and FREL) have some similar characteristics. Their interaction with lipids leads to a reduction in lipoprotein–lipid hydroperoxides that releases HDL-associated antioxidant enzymes, such as paraoxonase, therefore providing antiatherosclerosis and anti-inflammatory activity. In addition, the peptide D-4F stimulates the formation and cycling of pre-β HDL. These amphipathic peptides appear to have therapeutic potential as oral agents.