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Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

2012; SPIE; Volume: 17; Issue: 7 Linguagem: Inglês

10.1117/1.jbo.17.7.076012

1560-2281

Muhammad Rameez Chatni, Jun Xia, Rebecca Sohn, Konstantin Maslov, Zijian Guo, Yu Shrike Zhang, Kun Wang, Younan Xia, Mark A. Anastasio, Jeffrey M. Arbeit, Lihong V. Wang,

Optical Imaging and Spectroscopy Techniques

With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.