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Heart to heart: from nuclearproteins to Emery-Dreifuss muscular dystrophy

1999; Oxford University Press; Volume: 8; Issue: 10 Linguagem: Inglês

10.1093/hmg/8.10.1847

1460-2083

Glenn E. Morris,

RNA regulation and disease

Emery-Dreifuss muscular dystrophy has some remarkably specific features, with only cardiac and skeletal tissues being affected. Equally remarkably, the disease is caused by mutations in widely expressed genes for the nuclear membrane/lamina proteins, emerin and lamin A/C. How do mutations in proteins at the heart of the cell lead to stiff joints and sudden heart failure? This and related questions are the subject of this review.