β-Carboline Alkaloids: Biochemical and Pharmacological Functions
2007; Bentham Science Publishers; Volume: 14; Issue: 4 Linguagem: Inglês
10.2174/092986707779940998
ISSN1875-533X
AutoresRihui Cao, Wenlie Peng, Zihou Wang, Anlong Xu,
Tópico(s)Analytical Chemistry and Chromatography
Resumoβ-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects, mammalians as well as human tissues and body fluids. These compounds are of great interest due to their diverse biological activities. Particularly, these compounds have been shown to intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase, and to interact with benzodiazepine receptors and 5-hydroxy serotonin receptors. Furthermore, these chemicals also demonstrated a broad spectrum of pharmacological properties including sedative, anxiolytic, hypnotic, anticonvulsant, antitumor, antiviral, antiparasitic as well as antimicrobial activities. In this review, we summerized the biochemical and pharmacological functions of β-carboline alkaloids. Keywords: Reviews, β-carbolines, biochemical, pharmacological, structrue-activity relationship
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