Artigo Revisado por pares

A Placebo-Controlled, Double-Blind, Cross-Over Trial of Flunarizine in Common Migraine

1986; SAGE Publishing; Volume: 6; Issue: 1 Linguagem: Inglês

10.1046/j.1468-2982.1986.0601007.x

ISSN

1468-2982

Autores

Per Soelberg Sørensen, Klaus Hansen, Jes Olesen,

Tópico(s)

Attention Deficit Hyperactivity Disorder

Resumo

After four weeks of medication-free baseline observation, 29 patients with common migraine randomly received flunarizine (10 mg daily) or placebo for a 16-week period. After four weeks wash-out they crossed treatments for another 16 weeks; 27 patients completed the trial. Compared with placebo, flunarizine significantly reduced the frequency of migraine attacks and the derived headache indices, but the duration and severity of single attacks remained unchanged (Mann-Whitney U-test). The effect of flunarizine increased during the 16-week treatment period and during the last four weeks the number of migraine attacks reduced to 50% compared to the wash-out period. The only side-effect of flunarizine was mild daytime sedation in three patients. It is concluded that flunarizine is a valuable new prophylactic agent for common migraine.

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