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Terahertz probe of individual subwavelength objects in a water environment

2014; Wiley; Volume: 8; Issue: 5 Linguagem: Inglês

10.1002/lpor.201300224

1863-8899

Luca Masini, Sandro Meucci, Ji-Hua Xu, Riccardo Degl’Innocenti, Fabrizio Castellano, Harvey E. Beere, D. A. Ritchie, Donatella Balduzzi, Roberto Puglisi, Andrea Galli, Fabio Beltram, Miriam S. Vitiello, Marco Cecchini, Alessandro Tredicucci,

Photonic and Optical Devices

Laser & Photonics ReviewsVolume 8, Issue 5 p. 734-742 Original Paper Terahertz probe of individual subwavelength objects in a water environment Luca Masini, Luca Masini NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorSandro Meucci, Sandro Meucci NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorJihua Xu, Jihua Xu NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorRiccardo Degl'Innocenti, Riccardo Degl'Innocenti NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorFabrizio Castellano, Fabrizio Castellano NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorHarvey E. Beere, Harvey E. Beere Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorDavid Ritchie, David Ritchie Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorDonatella Balduzzi, Donatella Balduzzi Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorRoberto Puglisi, Roberto Puglisi Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorAndrea Galli, Andrea Galli Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorFabio Beltram, Fabio Beltram NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorMiriam S. Vitiello, Miriam S. Vitiello NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorMarco Cecchini, Marco Cecchini NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorAlessandro Tredicucci, Corresponding Author Alessandro Tredicucci NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalyCorresponding author: e-mail: a.tredicucci@sns.itSearch for more papers by this author Luca Masini, Luca Masini NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorSandro Meucci, Sandro Meucci NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorJihua Xu, Jihua Xu NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorRiccardo Degl'Innocenti, Riccardo Degl'Innocenti NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorFabrizio Castellano, Fabrizio Castellano NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorHarvey E. Beere, Harvey E. Beere Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorDavid Ritchie, David Ritchie Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, CB3 0HE UKSearch for more papers by this authorDonatella Balduzzi, Donatella Balduzzi Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorRoberto Puglisi, Roberto Puglisi Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorAndrea Galli, Andrea Galli Istituto Sperimentale Italiano ''Lazzaro Spallanzani'', Località LaQuercia, 26027—Rivolta d'Adda, Cremona, ItalySearch for more papers by this authorFabio Beltram, Fabio Beltram NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, ItalySearch for more papers by this authorMiriam S. Vitiello, Miriam S. Vitiello NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorMarco Cecchini, Marco Cecchini NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalySearch for more papers by this authorAlessandro Tredicucci, Corresponding Author Alessandro Tredicucci NEST, Istituto Nanoscienze – CNR and Scuola Normale Superiore, Piazza San Silvestro 12, Pisa, I-56127 ItalyCorresponding author: e-mail: a.tredicucci@sns.itSearch for more papers by this author First published: 04 June 2014 https://doi.org/10.1002/lpor.201300224Citations: 7Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Terahertz (THz) spectroscopy and imaging have been heralded for some time as potentially revolutionary techniques for biomedical applications. Label-free detection of molecules and recognition of molecular events are often mentioned as the most exciting possibilities. A crucial practical goal, however, is the ability to perform such measurements on tiny amounts of biological fluids or even on individual organic structures. Living cells, for instance, have diameters at most of some tens of micrometers, i.e. at least λ/10 even for few-THz radiation. Furthermore, all analyses relevant for a biological perspective must be performed in a water environment, which presents a strong absorption across the whole THz spectral range, severely limiting the penetration of the electromagnetic field. Here, it is shown how both issues can be overcome with a lab-on-a-chip approach based on a microfluidic platform coupled to a plasmonic antenna. Using a quantum cascade laser as THz illumination source, liquid volumes down to the picoliter range are probed, and direct operation on individual 10-µm diameter microparticles flowing in water is shown. The present demonstration opens the way to the development of THz biosensing of individual living cells and small probe volumes. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description lpor201300224-sup-0001-SupMat.pdf823.6 KB Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume8, Issue5September 2014Pages 734-742 RelatedInformation