Portal de Periódicos da CAPES

Pharmacotherapy of Unstable Angina

1992; Wiley; Volume: 32; Issue: 5 Linguagem: Inglês

10.1002/j.1552-4604.1992.tb03852.x

1552-4604

L. Michael Prisant, Thomas von Dohlen, Ward Rogers, Lauren C. Houghton, Albert A. Carr, Martin J. Frank,

Hormonal Regulation and Hypertension

The Journal of Clinical PharmacologyVolume 32, Issue 5 p. 390-399 Pharmacotherapy of Unstable Angina L. Michael Prisant MD, FCP, Corresponding Author L. Michael Prisant MD, FCP Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Associate Professor of Medicine, Medical College of Georgia, A F-2033, Augusta, GA 30912–3150.Search for more papers by this authorThomas von Dohlen MD, Thomas von Dohlen MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorWard Rogers MD, Ward Rogers MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorL. Houghton MD, L. Houghton MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorAlbert A. Carr MD, FCP, Albert A. Carr MD, FCP Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorMartin J. Frank MD, Martin J. Frank MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this author L. Michael Prisant MD, FCP, Corresponding Author L. Michael Prisant MD, FCP Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Associate Professor of Medicine, Medical College of Georgia, A F-2033, Augusta, GA 30912–3150.Search for more papers by this authorThomas von Dohlen MD, Thomas von Dohlen MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorWard Rogers MD, Ward Rogers MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorL. Houghton MD, L. Houghton MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorAlbert A. Carr MD, FCP, Albert A. Carr MD, FCP Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this authorMartin J. Frank MD, Martin J. Frank MD Sections of Hypertension & Cardiology, Departments of Medicine & Radiology, Medical College of Georgia, Augusta, Georgia.Search for more papers by this author First published: May 1992 https://doi.org/10.1002/j.1552-4604.1992.tb03852.xCitations: 6AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 von Dohlen TW, Rogers WB, Frank MJ: Pathophysiology and management of unstable angina. Clin Cardiol 1989; 12: 363–369. 2 The Criteria Committee of the New York Heart Association: Nomenclature and Criteria for the Diagnosis of Diseases of the Heart and Great Vessels. ( 8th edition) Boston, MA: Little, Brown and Company 1979; 288–289. 3 Oliva PB: Unstable rest angina with ST-segment depression. Pathophysiologic considerations and therapeutic implications. Ann Intern Med 1984; 100: 424–440. 4 Ambrose JA, Alexopoulos D: Thrombolysis in unstable angina: Will the beneficial effects of thrombolytic therapy in myocardial infarction apply to patients with unstable angina J Am Coll Cardiol 1989; 13: 1666–1671. 5 Gazes PC, Mobley EM, Faris HM, Duncan RC, Humphries GB: Preinfarction (unstable) angina — A prospective study — ten year follow-up: Prognostic significance of electrocardiographic changes. Circulation 1973; 48: 331–337. 6 National Center for Health Statistics: Vital and Health Statistics: Detailed Diagnosis and Procedures for Patients Discharged from Short-Stay Hospitals. US Department of Health and Human Services, Public Health Service, Series 13, No. 90, Hyattsville, MD, 1987. 7 Smitherman TC: Southwestern Internal Medicine Conference: Unstable angina pectoris: The first half century. Natural history, pathophysiology, and treatment. Am J Med Sci 1986; 292: 395–406. 8 Théroux P: A pathophysiologic basis for the clinical classification and management of unstable angina. Circulation 1987; 75 (Suppl. V): V103–V109. 9 Bosch X, Théroux P, Waters DD, Pelletier GB, Roy D: Early postinfarction ischemia: Clinical, angiographic, and prognostic significance. Circulation 1987; 75: 988–995. 10 Gore JM, Becker RC: Management of post-infarction angina. Cardiol Clin 1988; 6: 165–172. 11 The TIMI Study Group: Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II Trial. N Engl J Med 1989; 320: 618–627. 12 Braunwald E: Unstable angina: A classification. Circulation 1989; 80: 410–414. 13 Mulcahy R, Daly L, Graham I, Hickey N, O'Donoghue S, Owens A, Ruane P, Tobin G: Unstable angina: Natural history and determinants of prognosis. Am J Cardiol 1981; 48: 525–528. 14 Mulcahy R, Awadhi AHA, de Buitleor M, Tobin G, Johnson H, Contoy R: Natural history and prognosis of unstable angina. Am Heart J 1985; 109: 753–758. 15 Davies MJ, Thomas AC: Plaque Assuring — The cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 1985; 53: 363–73. 16 Falk E: Unstable angina with fatal outcome: Dynamic coronary thrombosis leading to infarction and/or sudden death. Circulation 1985; 71: 699–708. 17 Fuster V, Badimon L, Cohen M, Ambrose JA, Badimon JJ, Chesebro J: Insights into the pathogenesis of acute ischemic syndromes. Circulation 1988; 77: 1213–1220. 18 Epstein SE, Palmeri ST: Mechanisms contributing to precipitation of unstable angina and acute myocardial infarction: Implications regarding therapy. Am J Cardiol 1984; 54: 1245–1252. 19 Hamm CW, Bleifeld W: Unstable angina: Current concepts of medical management. Cardiovasc Drug Ther 1988; 2: 333–339. 20 Patterson DLH: Unstable angina. Postgrad Med J 1988; 64: 196–200. 21 Russell RO, Moraski RE, Kouchoukos N, Karp R, et al: Unstable angina pectoris: National Cooperative Study Group to compare surgical and medical therapy: II. In-hospital experience and initial follow-up results in patients with one, two and three vessel disease. Am J Cardiol 1978; 42: 839–848. 22 Moise A, Théroux P, Taeymans Y, Descoings B, Lésprance J, Waters DD, Pelletier GB, Bourassa M: Unstable angina and progression of coronary atherosclerosis. N Engl J Med 1983; 309: 685–689. 23 Ambrose JA, Winters SL, Arora RR, Eng A, Riccio A, Gorlin R, Fuster V: Angiographic evolution of coronary artery morphology in unstable angina. J Am Coll Cardiol 1986; 7: 472–478. 24 Williams AE, Freeman MR, Chisholm RJ, Patt NL, Armstrong PW: Angiographic morphology in unstable angina pectoris. Am J Cardiol 1988; 62: 1024–1027. 25 Sherman CT, Litvack F, Grundfest W, Lee M, Hickey A, Chaux A, Kass R, Blanche C, Matloff J, Morgenstern L, Ganz W, Swan HJC, Forrester J: Coronary angioscopy in patients with unstable angina pectoris. N Engl J Med 1986; 315: 913–919. 26 Patterson DLH: Management in unstable angina. Postgrad Med J 1988; 64: 271–277. 27 Lewis HD, Davis JW, Archibald DG, Steinke WE, Smitherman TC, Doherty JE, Schnaper HW, LeWinter MM, Linares E, Pouget JM, Sabharwal SC, Chesler E, DeMots H: Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: Results of a Veterans Administration Cooperative Study. N Engl J Med 1983; 309: 396–403. 28 Lewis HD: Unstable angina: status of aspirin and other forms of therapy. Circulation 1985; 72(Suppl. V): V-155–V-160. 29 Cairns JA, Gent M, Singer J, Finnie KJ, Froggatt GM, Holder DA, Jablonsky G, Kostuk WJ, Melendez LJ, Myers MG, Sackett DL, Sealey BJ, Tanser PH: Aspirin, sulfinpyrazone, or both in unstable angina: Results of a Canadian multicenter trial. N Engl J Med 1985; 313: 1369–1375. 30 Baisano F, Rizzon P, Violi F, Scrutinio D, Cimminiello C, Aguglia F, Pasotti C, Rudelli G and the studio della Ticlopidina nell' Angina Instabile Group: Anti platelet treatment with ticlopidine in unstable angina: A controlled multicenter clinical trial. Circulation 1990; 82: 17–26. 31 Gent M, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW, Panak E, Roberts RS, et al: The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1989; 2: 1216–1220. 32 Hass WK, Easton JD, Adams HP, Pryse-Phillips W, Molony BA, Anderson S, Kamm B: A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med 1989; 321: 501–507. 33 Thérpux P, Ouimet H. McCans J. Latour J, Joly P, Lévy G, Pelletier E, Juneau M, Stasiak J, de Guise P, Pelletier GB, Rinzler D, Waters DD: Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 1988; 319: 1105–1111. 34 Topol EJ, Nicklas JM, Kander NH, Walton JA, Ellis SG, Gorman L, Pitt B: Coronary revasularization after intravenous tissue plasminogen activator for unstable angina pectoris: Results of a randomized, double-blind, placebo-controlled trial. Am J Cardiol 1988; 62: 368–371. 35 Nicklas JM, Topol EJ, Kander N, O'Neill WW, Walton JA, Ellis SG, Gorman L, Pitt B: Randomized, double-blind, placebo-controlled trial of tissue plasminogen activator in unstable angina. J Am Coll Cardiol 1989; 13: 434–441. 36 Williams DO, Topol EJ, Califf RM, Roberts R, Mancini J, Joelson JM, Ellis SG, Kleiman NS: Intravenous recombinant tissue-type plasminogen activator in patients with unstable angina pectoris. Results of a placebo-controlled, randomized trial. Circulation 1990; 82: 376–383. 37 Serneri GGN, Gensini GF, Pogessi L, Trotta F, Modesti PA, Boddi M, Ieri A, Margheri M, Casolo GC, Bini M, Rostagno C, Carnovali M, Abbate R: Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina. Lancet 1990; 335: 615–618. 38 De Zwann C, Bar FW, Janssen JHA, de Swart HB, Vermeer F, Wellens HJ: Effects of thrombolytic therapy in unstable angina: Clinical and angiographic results. J Am Coll Cardiol 1988; 12: 301–309. 39 Gold HK, Johns JA, Leinbach RC, Yasuda T, Grossbard E, Zusman R, Collen D: A randomized, blinded, placebo-controlled trial of recombinant human tissue-type plasminogen activator in patients with unstable angina pectoris. Circulation 1987; 75: 1192–1199. 40 Gotoh K, Minamino T, Katoh O, Hamano Y, Fukui S, Hori M, Kusuoka H, Mishima M, Inoue M, Kamado T: The role of intracoronary thrombus in unstable angina: Angiographic assessment and thrombolytic therapy during ongoing angina attacks. Circulation 1988; 77: 526–534. 41 Ambrose JA, Hjemdahl-Monsen C, Borrico S, Sherman W, Cohen M, Gorlin R, Fuster V: Quantitative and qualitative effects of intracoronary streptokinase in unstable angina and non-Q wave infarction. J Am Coll Cardiol 1987; 9: 1156–1165. 42 Lawrence JR, Shepherd JT, Bone I, Rogen AS, Fulton WFM: Fibrinolytic therapy in unstable angina pectoris: A controlled clinical trial. Thromb Res 1980; 17: 767–777. 43 Sorkin EM, Brogden RN, Romankiewicz JA: Intravenous glyceryl trinitrate (nitroglycerin): A review of its pharmacological properties and therapeutic efficacy. Drugs 1984; 27: 45–80. 44 Norlander R: Use of nitrates in the treatment of unstable angina. Drugs 1987; 33 (Suppl. 4): 131–139. 45 Conti CR: Use of nitrates in unstable angina pectoris. Am J Cardiol 1987; 60: 31H–34H. 46 Depace NL, Herling IM, Kotler MN, Hakki A, Spielman SR, Segal BL: Intravenous nitroglycerin for rest angina. Potential pathophysiologic mechanism of action. Arch Intern Med 1982; 142: 1806–1809. 47 Page A, Gateau P, Ohayon J, Coupillaud J, LeMinh D, Besse P: Intravenous nitroglycerin in unstable angina, in PR Lichtlen, H-J Engel, A Schrey, HJC Swan (Eds). Nitrates III. Cardiovascular effects. Berlin: Springer-Verlag, 1981; 371–376. 48 Mikolich JR. Nicoloff NB, Robinson PH, Logue RB: Relief of refractory angina with continuous intravenous infusion of nitroglycerin. Chest 1980; 77: 375–379. 49 Kaplan K, Davison R, Parker M, Przybylek J, Teagarden JR, Lesch M: Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy. Am J Cardiol 1983; 51: 694–698. 50 Curfman GD, Heinsimer JA, Lozner EC, Fung H: Intravenous nitroglycerin in the treatment of spontaneous angina pectoris: A prospective, randomized trial. Circulation 1983; 67: 276–282. 51 May DC, Popma JJ, Black WH, Schaefer S, Lee HR, Levine BD, Hillis LD: In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. N Engl J Med 1987; 317: 805–809. 52 Packer M, Lee WH, Kessler PD, Gottlieb SS, Medina N, Yushak M: Prevention and reversal of nitrate tolerance in patients with congestive heart failure. N Engl J Med 1987; 799–804. 53 Zimrin D, Reichek N, Bogin KT, Aurigemma G, Douglas P, Berko B, Fung HL: Antianginal effects of intravenous nitroglycerin over 24 hours. Circulation 1988; 77: 1376–84. 54 Horowitz JD, Henry CA, Syrjanen ML, Louis WJ, Fish RD, Smith TW, Antman EM: Combined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris. Circulation 1988; 77: 787–794. 55 Habbab MA, Haft JI: Heparin resistance induced by intravenous nitroglycerin: A word of caution when both drugs are used concomitantly. Arch Intern Med 1987; 147: 857–860. 56 Lepor NE, Amin DK, Shah PK: Does nitroglycerin induce heparin resistance Clin Cardiol 1989; 12: 432–434. 57 Becker RC, Corrao JM, Bovill EG, Gore JM, Baker SP, Miller ML, Lucas FV, Alpert JA: Intravenous nitroglycerin-induced heparin resistance: A qualitative antithrombin III abnormality. Am Heart J 1990; 119: 1254–1260. 58 Yusuf S, Wittes J, Friedman L: Overview of results of randomized clinical trials in heart disease: II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification. JAMA 1988; 260: 2259–2263. 59 Yusuf, Peto R, Lewis J, Collins R, Sleight P: Beta blockade during and after myocardial infarction: An overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335–371. 60 Yusuf S: The use of beta-blockers in the acute phases of myocardial infarction, in RM Califf, GS Wagner (Eds): Acute Coronary Care Boston: Martinus Nijhoff Publishing 1985; 73–88. 61 Vedin A, Wilhelmsson: Medical treatment of ischaemic heart disease-Beta-blockers. Eur Heart J 1985; 6(Suppl A): 13–27. 62 Yusuf S, Ramsdale D, Peto R, Furse L, Bennett D, Bray C, Sleight P: Early intravenous atenolol treatment in suspected acute myocardial infarction. Lancet 1980; 2: 273–276. 63 Norris RM, Clarke ED, Sammel NL, Smith WM, Williams B: Protective effect of propranolol in threatened myocardial infarction. Lancet 1978; 2: 907–909. 64 Yusuf S, Sleight P, Rossi P, Ramsdale D, Peto R, Furze L, Sterry H, Pearson M, Morwani R, Parrish S, Gray R, Bennet D, Bray C: Reduction in infarct size, arrhythmias, and chest pain by early intravenous beta blockade in suspected acute myocardial infarction. Circulation 1983; 67(part 2): 32–41. 65 The MIAMI Trial Research Group: Metoprolol in acute myocardial infarction (MIAMI): A randomised, placebo-controlled international trial. Eur Heart J 1985; 6: 199–226. 66 ISIS-1 Collaborative Group: Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial infarction: ISIS-1 Lancet 1986; 2: 57–66. 67 Schneider W, Kaltenbach: The use of β-blockers in unstable angina: Comparison with calcium channel blocking agents. J Cardiovasc Pharmacol 1988; 12(Suppl. 1): S78–S82. 68 Gottlieb SO, Gerstenblith G: Therapeutic choices in unstable angina. Am J Med 1986; 80(Suppl. 4C): 35–39. 69 Zelis R: Calcium-blocker therapy for unstable angina pectoris. N Engl J Med 1982; 306: 926–928. 70 Beller GA: Calcium antagonists in the treatment of Prinzmetal's angina and unstable angina pectoris. Circulation 1989; 80(Suppl. IV): IV-78–IV-87. 71 Muller JE, Morrison J, Stone PH, Rude RE, Rosner B, Roberts R, Pearle DL, et al: Nifedipine therapy for patients with threatened and acute myocardial infarction: A randomized, double-blind, placebo-controlled comparison. Circulation 1984; 69: 740–747. 72 Muller JE, Turi ZG, Pearle DL, Schneider JF, Serfas DH, Morrison J, Stone PH, et al: Nifedipine and conventional therapy for unstable angina pectoris: A randomized, double-blind comparison. Circulation 1984; 69: 728–739. 73 Holland Interuniversity Nifedipine/Metoprolol Trial (HINT) Research Group: Early treatment of unstable angina in the coronary care unit: a randomised, double blind, placebo controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both. Br Heart J 1986; 56: 400–413. 74 Crea F, Deanfield J, Crean P, Sharom M, Davies G, Maseri A: Effects of verapamil in preventing early postinfarction angina and reinfarction. Am J Cardiol 1985; 55: 900–904. 75 Mehta J, Pepine CJ, Day M, Guerrero JR, Conti CR: Short-term efficacy of oral verapamil in rest angina: A double-blind placebo controlled trial in CCU patients. Am J Med 1981; 71: 977–982. 76 Parodi O, Maseri A, Simonetti I: Management of unstable angina at rest by verapamil. A double-blind crossover study in coronary care unit. Br Heart J 1979; 41: 167–174. 77 Parodi O, Simonetti I, Michelassi C, Carpeggiani C, Biagini A, L'Abbate A, Maseri A: Comparison of verapamil and propranolol therapy for angina pectoris at rest: A randomized, multiple-crossover, controlled trial in the coronary care unit. Am J Cardiol 1986; 57: 899–906. 78 Théroux P, Taeymans Y, Morissette, Bosch X, Pelletier GB, Waters DD: A randomized study comparing propranolol and diltiazem in the treatment of unstable angina. J Am Coll Cardiol 1985; 5: 717–722. 79 Held PH, Yusuf S, Furberg CD: Calcium channel blockers in acute myocardial infarction and unstable angina: An overview. Br Med J 1989; 299: 1187–1192. 80 Lichstein E, Mendizabal R, Théroux P, Muller O, Willerson JT, Rapaport E, Molk BL, Linet OI: Epoprostenol (prostacyclin) in unstable angina. J Clin Pharmacol 1988; 28: 300–305. 81 Black JR: Role of coronary angioplasty in the management of unstable angina pectoris. Cardiovasc Rev Reports 1990; 24–29. 82 de Feyter PJ: Coronary angioplasty for unstable angina. Am Heart J 1989; 118: 860–867. 83 Kaiser GC, Schaff HV, Killip T: Myocardial revascularization for unstable angina pectoris. Circulation 1989; 79(Suppl. I): 160–167. 84 Luchi RJ, Scott SM, Deupree RH et al: Comparison of medical and surgical treatment for unstable angina pectoris. Results of a Veterans Administration Cooperative Study. N Engl J Med 1987; 316: 977–984. 85 Parisi AF, Khuri S, Deupree RH, Sharma GVRK, Scott SM, Luchi RJ: Medical compared with surgical management of unstable angina. 5-year mortality and morbidity in the Veterans Administration Study. Circulation 1989; 80: 1176–1189. Citing Literature Volume32, Issue5May 1992Pages 390-399 ReferencesRelatedInformation