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A Structural Model of the Chloramphenicol Receptor Site

1975; Springer Vienna; Linguagem: Inglês

10.1007/978-3-7091-8405-9_17

0171-2160

Fred E. Hahn, Peter Gund,

Analytical Chemistry and Chromatography

Having a relatively simple chemical structure, chloramphenicol became the first antibiotic to be synthesized by organic-chemical methods (Controulis, Rebstock and Crooks, 1949). A large number of chloramphenicol derivatives was subsequently prepared. Kolosov, Shemiakin, Khokhlov and Gurevich tabulated, in 1961, more than 500 such compounds, and the total number of known chloramphenicol derivatives is, by now, much greater.