Portal de Periódicos da CAPES

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

2011; Cell Press; Volume: 20; Issue: 2 Linguagem: Inglês

10.1016/j.ccr.2011.07.007

1878-3686

Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Benner, Thomas Hielscher, Till Milde, Marc Remke, David Jones, Paul A. Northcott, Livia Garzia, Kelsey C. Bertrand, Andrea Wittmann, Yuan Yao, Stephen S. Roberts, Luca Massimi, Timothy Van Meter, William A. Weiss, Nalin Gupta, Wiesława Grajkowska, Bolesław Lach, Yoon-Jae Cho, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Gary D. Bader, Cynthia Hawkins, Uri Tabori, Abhijit Guha, James T. Rutka, Peter Lichter, Andrey Korshunov, Michael D. Taylor, Stefan M. Pfister,

Advanced Electron Microscopy Techniques and Applications

Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymoma reveals the existence of two demographically, transcriptionally, genetically, and clinically distinct groups of posterior fossa (PF) ependymomas. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis at recurrence, and death compared with Group B patients. Identification and optimization of immunohistochemical (IHC) markers for PF ependymoma subgroups allowed validation of our findings on a third independent cohort, using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.