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The Relationship of Cardiovascular Disease to Hyperglycemia

1965; American College of Physicians; Volume: 62; Issue: 6 Linguagem: Inglês

10.7326/0003-4819-62-6-1188

1539-3704

Leon D. Ostrander,

Lipoproteins and Cardiovascular Health

Article1 June 1965The Relationship of Cardiovascular Disease to HyperglycemiaLEON D. OSTRANDER JR., M.D., F.A.C.P., THOMAS FRANCIS JR., M.D., SC.D., NORMAN S. HAYNER, M.D., MARCUS O. KJELSBERG, PH.D., FREDERICK H. EPSTEIN, M.D.LEON D. OSTRANDER JR., M.D., F.A.C.P., THOMAS FRANCIS JR., M.D., SC.D., NORMAN S. HAYNER, M.D., MARCUS O. KJELSBERG, PH.D., FREDERICK H. EPSTEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-6-1188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe high prevalence of vascular disease among diabetics has long been recognized and has become increasingly important since the acute complications of diabetes, acidosis, and infection have been controlled. With a longer life span cardiovascular disease is now the major complication of diabetes. Only 17% of diabetics died of vascular disease in 1914, but by 1957 it was the cause of death in 77% of the patients in one large series (1). Besides the well-known capillary lesions, the vascular complications have included coronary and peripheral atherosclerotic occlusive disease, hypertension, and cerebrovascular disease.The higher prevalence and greater severity of coronary...References1. ROOTBRADLEY HFRF: Cardiovascular-renal disease, in The Treatment of Diabetes Mellitus, 10th ed., edited by JOSLIN, E. P., ROOT, H. F., WHITE, P., MARBLE, A. Lea & Febiger, Philadelphia, 1959, p. 408. Google Scholar2. LISAMAGIDAYGALLOWAYHART JRMIJF: Arteriosclerosis with diabetes mellitus. JAMA 120: 192, 1942. CrossrefGoogle Scholar3. STEARNSSCHLESINGERRUDY SMJA: Incidence and clinical significance of coronary artery disease in diabetes mellitus. Arch. Intern. Med. (Chicago) 80: 463, 1947. CrossrefGoogle Scholar4. BELL ET: A post mortem study of vascular disease in diabetics. Arch. Path. 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OSTRANDERJR., M.D., F.A.C.P.; THOMAS FRANCISJR., M.D., SC.D.; NORMAN S. HAYNER, M.D.; MARCUS O. KJELSBERG, PH.D.; FREDERICK H. EPSTEIN, M.D.Affiliations: Ann Arbor, MichiganFrom the Department of Epidemiology, The University of Michigan School of Public Health, Ann Arbor, Mich.This study was supported by Program Project Grant HE-06378 from the National Heart Institute, National Institutes of Health, U. S. Public Health Service, and Research Career Award HE-K6-6748 to Dr. Epstein from the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Leon D. Ostrander, Jr., M.D., Department of Epidemiology, The University of Michigan, School of Public Health, Ann Arbor, Mich. 48104. 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The role of insulinHyperglycaemia and coronary heart disease: The Whitehall StudyThe relationship between post-load plasma glucose and blood pressure at different resting heart ratesHydrolase activities in the rat aorta. I. Effects of diabetes mellitus and insulin treatment.Usefulness of serum lipid determination in diabetic practiceBlood Sugar and Serum Insulin Levels in Jamaica, West IndiesGlucose tolerance and physical fitness: An epidemiologic study in an entire community6 Diabetes and the heart: Coronary heart diseaseEffects of Diabetes Mellitus on Cholesterol Metabolism in ManDifferences in cardiovascular morbidity and mortality between previously known and newly diagnosed adult diabeticsThe relationship of abnormal circulating insulin levels to atherosclerosisSerum and liver lipid responses to 3-hydroxy-3-methylglutaric acid in rats on different carbohydrate dietsThe Effect of Clofibrate on Glucose Tolerance, Insulin Secretion, Triglycerides and Fibrinogen in Patients with Coronary Heart DiseaseIntravenous Glucose Tolerance Test in Middle-Aged Men with and without Latent Coronary Heart DiseaseExercise tests in individuals with borderline glucose tolerance and varying smoking habitsPlethysmographic studies in individuals with borderline glucose tolerance and varying smoking habitsDie diabetische MakroangiopathieRole of alimentary hyperglycemia in the pathogenesis of some disturbances of lipid metabolismDiabetes, prediabetes and uricaemiaThe Chemistry of AngiopathyTHE ROLE OF NUTRITION TO DIABETES IN RELATION TO AGEMultivariate analysis of the relationship of six variables to blood pressure: Findings from Chicago Community Surveys, 1965–1971Hyperlipoproteinemia and Inner Ear DiseaseDiabetes as a Risk Factor for Arteriosclerotic Vascular DiseaseMisunderstanding or error?Altered Myocardial Function and Metabolism in Chronic Diabetes Mellitus without Ischemia in DogsL'Aterosclerosi ed i suoi fattori di rischioLIST OF REFERENCESReferencesREFERENCESFive-year myocardial infarction incidence—II. Association of single variables to age and birthplaceTreatment of chemical diabetes mellitus with sulfonylurea compoundsCoronary Heart Disease in Young Men: A Study of Seventy Patients with a Critical Review of Etiological Factors*REFERENCESREFERENCESMacroangiopathy — Its Prevalence in Asymptomatic DiabetesAltered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, MichiganChapter 19. AtherosclerosisGlucose tolerance, plasma lipids and atherosclerosisPermanent Ventricular Pacing Effect on Long-Term Survival, Congestive Heart Failure, and Subsequent Myocardial Infarction and StrokeDENNIS M. DAVIDSON, M.D., CHARLES A. BRAAK, B.A., THOMAS A. PRESTON, M.D., RICHARD D. JUDGE, M.D., F.A.C.P.DIABETES DETECTION IN MASS HEALTH EXAMINATIONS THREE–YEAR EXPERIENCE FROM BUSSELTONAbnormalities in Glucose Tolerance, Lipid and Lipoprotein Levels in Patients With Atherosclerotic Peripheral Arterial DiseaseGLUCOSE TOLERANCE, PLASMA INSULIN AND LIPIDS IN RELATION TO ADIPOSE TISSUE CELLULARITY IN MEN AFTER MYOCARDIAL INFARCTIONThe effect of insulin deficiency, hypothyroidism, and hypertension on atherosclerosis in the squirrel monkeySerum cholesterol and triglycerides during mild glucose intoleranceFactors related to diabetes incidence: A multivariate analysis of two years observation on 10,000 menFacteurs diététiques et cardiopathies coronariennesCoronary Disease and Carbohydrate and Fat AbnormalitiesDetection of individual susceptibility toward coronary diseaseNutrition and Cardiovascular DiseaseBibliographyThe Tecumseh StudyEmotional stress, physical activity and ischemic heart diseaseDiabetes screening during pregnancyThe status of risk factors and coronary heart diseaseReferencesResults of the Epidemologic Investigation of Ischaemic Heart Disease: Illustrated by the Framingham StudyPossible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870)Effect of Aging on Carbohydrate MetabolismHyperglycemia and Vascular Disease in Tecumseh, MichiganMinimal Diabetes and Arterial Disease: Prevalence and the Effect of TreatmentPlatelet aggregation and thrombus formation in diabetes mellitus: An in vitro studyInsulin Resistance and Cardiovascular DiseaseClinical and Biological Observations on Working MenMetabolic basis of human atherosclerosisHEALTH MAINTENANCE IN OLDER ADULTSRisk factors for coronary heart disease in Hawaiian and Japanese males in Hawaii.Hypertension in indian diabeticsEnvironmental Health and the Older AdultWhat can be done to retard ageing and to increase expectation of life?Coronary heart disease in HawaiiA LONG-TERM CORONARY PREVENTION EVALUATION PROGRAMDIABETES DETECTED BY BLOOD‐SUGAR MEASUREMENT AFTER A GLUCOSE LOAD: REPORT FROM THE BUSSELTON SURVEY, 1966Alterations of Factors Predisposing to Coronary Heart DiseaseLEON D. OSTRANDER JR., M.D., F.A.C.P.Normokaliämischer primärer AldosteronismusPlasma lipids and glucose in normal health, diabetes and cardiovascular diseaseMETABOLIC ABNORMALITIES IN PREMATURE CORONARY DISEASE: EFFECTS OF THERAPYTHE PREVENTION OF CORONARY HEART DISEASEON THE PREVALENCE OF ADRENOCORTICAL ADENOMAS IN AN AUTOPSY MATERIAL IN RELATION TO HYPERTENSION AND DIABETESGLUCOSE TOLERANCE, PLASMA LIPIDS AND SERUM INSULIN IN PATIENTS WITH ISCHAEMIC HEART DISEASESThe Detection of Diabetes in ManGlucose Tolerance in Ischaemic Cardiovascular DiseaseStudies of thrombus formation and fatty acid composition of serum lecithins and cephalins in man during high sugar and starch dietsFactors contributing to the ballistocardiographic waveform in healthy middle-aged menSPECIAL ARTICLEThe Exercise Test in Diabetic Patients as Studied by RadioelectrocardiographyHyperglycemia and Hypertriglyceridemia Among Persons with Coronary Heart DiseaseLEON D. OSTRANDER JR., M.D., F.A.C.P., BEVERLY J. NEFF, PH.D., WALTER D. BLOCK, PH.D., THOMAS FRANCIS JR., M.D., SC.D., FREDERICK H. EPSTEIN, M.D.Serum Insulin, Carbohydrate, and Lipid Abnormalities in Patients with Premature Coronary Heart DiseaseMANUEL TZAGOURNIS, M.D., JOHN F. SEIDENSTICKER, M.D., GEORGE J. HAMWI, M.D., F.A.C.P.Detection of coronary-prone subjects in a normal population by radioelectrocardiographic exercise testGLUCOSE TOLERANCE, AGE, AND CIRCULATING INSULINConstitutional and Environmental Factors Related to Serum Lipid and Lipoprotein LevelsWILLIAM R. HARLAN JR., M.D., ALBERT OBERMAN, M.D., ROBERT E. MITCHELL, M.D., ASHTON GRAYBIEL, M.D.Myocardial infarction in Hawaiian and Japanese males on Oahu—A review of 505 cases occurring between 1955 and 1964DIETARY FAT AND CORONARY HEART DISEASE: A REVIEWCybernetics of blood sugar and fat in health and diseaseORAL CONTRACEPTIVES AND CARDIOVASCULAR DISEASEORAL CONTRACEPTIVES AND THYROID STATUSGLUCOSE TOLERANCE AND ATHEROSCLEROSISGLUCOSE TOLERANCE IN HYPERTENSIVE PATIENTS ON LONG-TERM DIURETIC THERAPYValue of Prospective StudiesThe Presymptomatic Diagnosis of DiabetesPresymptomatic Diagnosis of Ischæmic Heart DiseaseSu taluni aspetti del metabolismo degli idrati di carbonio in corso di aterosclerosiAbsence of peripheral pulse in relation to other arterial disease in a community study.SERUM-INSULIN IN ESSENTIAL HYPERTENSION AND IN PERIPHERAL VASCULAR DISEASEFamilial Aggregation of Factors Associated with Coronary Heart DiseaseHypertension, Diabetes and the Adrenal GlandsCoronary-Artery Disease in Identical TwinsExercise Tests in Male DiabeticsREFERENCESCoronary Risk FactorsEFFECT OF SIMPLE AND COMPLEX CARBOHYDRATES ON PLASMA NON-ESTERIFIED FATTY ACIDS, PLASMA-SUGAR, AND PLASMA-INSULIN DURING ORAL CARBOHYDRATE TOLERANCE TESTSHypertension, the Potassium Ion and Impaired Carbohydrate ToleranceInsulin resistance in hyperglyceridemiaMARGINAL UNDERNUTRITIONBLOOD-SUGAR AND ARTERIAL DISEASEPOTASSIUM CHLORIDE AND INTESTINAL ULCERATIONDIET AND MYOCARDIAL INFARCTIONEpidemiological Studies of Cardiovascular Disease in a Total Community—Tecumseh, MichiganFREDERICK H. EPSTEIN, M.D., LEON D. OSTRANDER JR., M.D., F.A.C.P., BENJAMIN C. JOHNSON, M.D., DR. P.H., MILLICENT W. PAYNE, M.D., D.P.H., NORMAN S. HAYNER, M.D., M.P.H., JACOB B. KELLER, M.P.H., THOMAS FRANCIS JR., M.D., D.SC.Carbohydrate Metabolism in Cardiovascular DiseaseMARGARET J. ALBRINK, M.D.Acceptability of Vegetables in an Army Mess1 1 June 1965Volume 62, Issue 6Page: 1188-1198KeywordsCardiovascular diseasesCardiovascular therapyCareers in researchCerebrovascular diseasesEpidemiologyHyperglycemiaHypertensionMedical servicesPrevention, policy, and public healthVascular diseases ePublished: 1 December 2008 Issue Published: 1 June 1965 PDF downloadLoading ...