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Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

2014; Elsevier BV; Volume: 148; Issue: 2 Linguagem: Inglês

10.1053/j.gastro.2014.10.041

1528-0012

Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay, Garry Farnham, Francesc Castro-Giner, Maikel P. Peppelenbosch, Michal Kováč, Claire Adams, Hans Prenen, Sarah Briggs, Rebecca Harrison, S. Sanders, David MacDonald, Chris Haigh, Art Tucker, Sharon Love, Manoj Nanji, John de Caestecker, David Ferry, B J Rathbone, Julie Hapeshi, Hugh Barr, Paul Moayyedi, Peter J. Watson, Barbara Zietek, Neera Maroo, Laura Gay, Timothy J. Underwood, Lisa Boulter, Hugh McMurtry, David Gabriel Monk, Praful Patel, Krish Ragunath, David Al Dulaimi, Iain Murray, Konrad Koss, Andrew Veitch, Nigel Trudgill, Chuka Nwokolo, Björn Rembacken, Paul Atherfold, Elaine Green, Yeng Ang, Ernst J. Kuipers, W H Chow, Stuart Paterson, Sudarshan Kadri, Ian Beales, Charles Grimley, Paul D. Mullins, Conrad Beckett, Mark Farrant, Andrew Dixon, Sean G. Kelly, Matthew E. Johnson, Saj Wajed, Anjan Dhar, Elinor J. Sawyer, Rebecca Roylance, Lynn Onstad, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Brian J. Reid, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, Alan G. Casson, Rebecca C. Fitzgerald, David C. Whiteman, Harvey A. Risch, David Levine, Tom L. Vaughan, Auke P. Verhaar, Jan Van den Brande, Eelke L.A. Toxopeus, Manon C.W. Spaander, Bas P. L. Wijnhoven, Luc J. W. van der Laan, Kausilia K. Krishnadath, Cisca Wijmenga, Gosia Trynka, Ross McManus, John V. Reynolds, Jacintha O’Sullivan, Padraic MacMathúna, Sarah A. McGarrigle, Dermot Kelleher, Séverine Vermeire, Isabelle Cleynen, Raf Bisschops, Ian Tomlinson, Janusz Jankowski,

Epigenetics and DNA Methylation

Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations.