Relation of myocardial T2* to right ventricular function in thalassaemia major
2010; Oxford University Press; Volume: 31; Issue: 13 Linguagem: Inglês
10.1093/eurheartj/ehq106
ISSN1522-9645
AutoresFrancisco Alpendurada, John Paul Carpenter, Monica Deac, Paul Kirk, John M. Walker, John B. Porter, Winston Banya, Tianle He, Gillian Smith, Dudley J. Pennell,
Tópico(s)Iron Metabolism and Disorders
ResumoMyocardial T2* cardiovascular magnetic resonance (CMR) provides a rapid and reproducible measure of cardiac iron loading and is being increasingly used worldwide for monitoring of transfusion-dependent thalassaemia patients. Although myocardial siderosis (T2* 20 ms), the RV ejection fraction (EF) was within the normal range in 98% of patients. When myocardial T2* was <20 ms, there was a progressive and significant decline in RV EF. There was a linear relationship between RV and LV EF. Myocardial iron deposition is strongly associated with RV dysfunction, which mirrors the decrease in LV function seen with worsening cardiac iron loading. Right ventricular dysfunction may play a significant role in heart failure associated with myocardial siderosis.
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