Produção Nacional
Prevalence, genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil
2011; Baishideng Publishing Group; Volume: 17; Issue: 25 Linguagem: Inglês
10.3748/wjg.v17.i25.3027
ISSN2219-2840
AutoresBruno Fernandes de Oliveira Santos, Nathalie Oliveira de Santana, Alex Vianey Callado França,
Tópico(s)HIV/AIDS drug development and treatment
ResumoAIM:To determine hepatitis C virus (HCV) seroprevalence and its genotypes, and to identify the factors associated with HCV infection. METHODS:This cross-sectional study, conducted in two prisons (one male and one female) in the State of Sergipe, Brazil, comprised 422 subjects.All of the prisoners underwent a rapid test for the detection of HCV antibodies.Patients with a positive result were tested for anti-HCV by enzyme linked immunosorbent assay and for HCV RNA by qualitative polymerase chain reaction (PCR).The virus genotype was defined in every serum sample that presented positive for PCR-HCV.In order to determine the factors independently associated with positive serology for HCV, multivariate logistic regression was used. RESULTS:HCV seroprevalence was 3.1%.Of the 13 subjects with positive anti-HCV, 11 had viremia confirmed by PCR.Of these, 90.9% had genotype 1.A total of 43 (10.2%) were injecting drug users, and HCV seroprevalence in this subgroup was 20.6%.The variable most strongly associated with positive serology for HCV was use of injecting drugs [odds ratio (OR), 23.3; 95% confidence interval (CI), 6.0-90.8].Age over 30 years (OR, 5.5; 95%CI, 1.1-29.2),history of syphilis (OR, 9.8; 95%CI, 1.7-55.2) and history of household contact with HCV positive individual (OR, 14.1; 95%CI, 2.3-85.4)were also independently associated with HCV infection. CONCLUSION:Most of the HCV transmissions result from parenteral exposure.However, there is evidence to suggest a role for sex and household contact with an infected subject in virus transmission.
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