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Common variants at VRK2 and TCF4 conferring risk of schizophrenia

2011; Oxford University Press; Volume: 20; Issue: 20 Linguagem: Inglês

10.1093/hmg/ddr325

1460-2083

Stacy Steinberg, Simone de Jong, Ole A. Andreassen, Thomas Werge, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Ómar Gústafsson, Javier Costas, Olli Pietiläinen, Ditte Demontis, Sergi Papiol, Johanna Huttenlocher, Manuel Mattheisen, René Breuer, Evangelos Vassos, Ina Giegling, Gillian Fraser, Nicholas Walker, Annamari Tuulio‐Henriksson, Jaana Suvisaari, Jouko Lönnqvist, Tiina Paunio, Ingrid Agartz, Ingrid Melle, Srdjan Djurovic, Eric Strengman, Gesche Jürgens, Birte Glenthøj, Lars Terenius, David M. Hougaard, Torben Ørntoft, Carsten Wiuf, Michael Didriksen, Mads V. Hollegaard, Merete Nordentoft, Ruud van Winkel, Günter Kenis, Л. И. Абрамова, В. Г. Каледа, Manuel Arrojo, Julio Sanjuán, Celso Arango, Swetlana Sperling, Moritz J. Rossner, Michele Ribolsi, Valentina Magni, Alberto Siracusano, Claus Christiansen, Lambertus A. Kiemeney, Jan H. Veldink, Leonard van den Berg, Andrés Ingason, Pierandrea Muglia, Robin M. Murray, Markus M. Nöthen, Engilbert Sigurðsson, Hannes Pétursson, Unnur Þorsteinsdóttir, Augustine Kong, I. Alex Rubino, Marc D. Binder, János Réthelyi, István Bitter, Erik G. Jönsson, В. Е. Голимбет, Ángel Carracedo, Hannelore Ehrenreich, Nick Craddock, Michael J. Owen, Michael O’Donovan, Mirella Ruggeri, Sarah Tosato, Leena Peltonen, Roel A. Ophoff, David Collier, David St Clair, Marcella Rietschel, Sven Cichon, Hreinn Stefánsson, Dan Rujescu, Kāri Stefánsson,

Genomics and Chromatin Dynamics

Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10−9] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10−9).