Proliferation of Functional Hair Cells in Vivo in the Absence of the Retinoblastoma Protein
2005; American Association for the Advancement of Science; Volume: 307; Issue: 5712 Linguagem: Inglês
10.1126/science.1106642
ISSN1095-9203
AutoresCyrille Sage, Mingqian Huang, Kambiz Karimi, Gabriel M. Gutierrez, Melissa A. Vollrath, Duan-Sun Zhang, Jaime García‐Añoveros, Philip W. Hinds, Jeffrey T. Corwin, David P. Corey, Zheng‐Yi Chen,
Tópico(s)melanin and skin pigmentation
ResumoIn mammals, hair cell loss causes irreversible hearing and balance impairment because hair cells are terminally differentiated and do not regenerate spontaneously. By profiling gene expression in developing mouse vestibular organs, we identified the retinoblastoma protein (pRb) as a candidate regulator of cell cycle exit in hair cells. Differentiated and functional mouse hair cells with a targeted deletion of Rb1 undergo mitosis, divide, and cycle, yet continue to become highly differentiated and functional. Moreover, acute loss of Rb1 in postnatal hair cells caused cell cycle reentry. Manipulation of the pRb pathway may ultimately lead to mammalian hair cell regeneration.
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