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Highly Regioselective Copper‐Catalyzed Benzylic CH Amination by N ‐Fluorobenzenesulfonimide

2011; Wiley; Volume: 51; Issue: 5 Linguagem: Inglês

10.1002/anie.201107427

1521-3773

Zhikun Ni, Qian Zhang, Tao Xiong, Yiying Zheng, Yan Li, Hongwei Zhang, Jingping Zhang, Qun Liu,

Asymmetric Hydrogenation and Catalysis

Primary target: A practical and effective copper-catalyzed amination strategy for synthesizing various benzylic amines from benzylic hydrocarbons is described (see scheme; DCE=1,2-dichloroethane). Xylene substrates can undergo diamination reactions using this method. The remarkable preference for primary over secondary benzylic CH bonds has been observed for the first time. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.