Synthesis, crystal structure determination and pharmacological activity of 7,8,3′,4′‐tetramethoxyisoflavone
1991; Wiley; Volume: 28; Issue: 8 Linguagem: Inglês
10.1002/jhet.5570280815
ISSN1943-5193
AutoresEsther Domı́nguez, Esther Lete, María‐Jesús Villa, A. Igartua, Nuria Sotomayor, Juan Manuel Arrieta, Agustin Berisa, Luis Labeaga, Aurelio Orjales, G. Germain, V. Nastopoulos,
Tópico(s)Phytochemistry and Biological Activities
ResumoAbstract 7 The8,3′,4′‐tetramethoxyisoflavone 2 was synthesized and its structure confirmed by X‐ray crystallographic analysis. Pharmacological screening was carried out with this compound in order to assess its pharmacological profile. Isoflavone 2 possessed antiinflamatory activity in the carrageenan oedema test, with a dose‐effect relationship comparable to that of hydroxylated flavonoids. It is noteworthy that 2 is one of the few isoflavones efficient as antiinflammatory with complete alkylation of hydroxyl groups.
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