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Type II collagen distribution in rodents

1988; Wiley; Volume: 98; Issue: 11 Linguagem: Inglês

10.1288/00005537-198811000-00019

1531-4995

T.J. Yoo, Koichi Tomoda,

Congenital Ear and Nasal Anomalies

Abstract The anatomical distribution of type II collagen in animal ears was studied by immunohistochemical techniques, using defined monoclonal antibodies to type II collagen. Type II collagen was observed in the cartilage plate of the auricle and external auditory meatus, tympanic annulus, lamina propria of tympanic membrane (pars tensa), interossicular joints, stapes footplate, eustachian tube cartilage, enchondral layer and globuli interossei of the otic capsule, Rosenthal canal, cribriform base, osseous spiral lamina, spiral ligament, limbus, tectorial membrane, semicircular canal membrane and subepithelial layer of the ampullary crista, utricular and saccular maculae, and the endolymphatic duct and proximal part of the sac. Thus, type II collagen should be considered as an important component of ear tissue that might act as a target organ in an immune response.