New Achievements in the Field of Intramolecular Phenolic Coupling Reactions, Using Hypervalent (III) Iodine Reagent: Synthesis of Galanthamine
2000; Taylor & Francis; Volume: 30; Issue: 16 Linguagem: Inglês
10.1080/00397910008087434
ISSN1532-2432
AutoresDikran Krikorian, Velichko Tarpanov, Stoyan Parushev, Pepa Mechkarova,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoAbstract Our investigations on the oxidative possibilities of the hypervalent iodine(III) reagent established that phenyliodine(III)bis(trifluoroacclate) (PIFA) can provide one-pot contiguous coupling-cyclization reaction giving a product with narwedine skeleton, when used in a phenolic coupling reaction of p'-bromonorbelladine derivatives. A suitably selected precursor gave up to 60% yield of the coupled product.
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