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Tetravalent meningococcal serogroups A, C, W-135 and Y conjugate vaccine is well tolerated and immunogenic when co-administered with measles–mumps–rubella–varicella vaccine during the second year of life: An open, randomized controlled trial

2011; Elsevier BV; Volume: 29; Issue: 25 Linguagem: Inglês

10.1016/j.vaccine.2011.03.043

1873-2518

Timo Vesikari, Aino Karvonen, Véronique Bianco, Marie Van der Wielen, Jacqueline M. Miller,

SARS-CoV-2 and COVID-19 Research

Co-administration of meningococcal ACWY-tetanus toxoid conjugate vaccine (ACWY-TT) with MMRV vaccine was investigated in 1000 12–23-month old children randomized (3:3:1:1) to receive co-administered ACWY-TT + MMRV, or a single dose of ACWY-TT, MMRV or MenC-CRM197. Non-inferiority of ACWY-TT to MenC-CRM197 and non-inferiority of ACWY-TT + MMRV to ACWY-TT and MMRV alone, and the immunogenicity of serogroups AWY were demonstrated according to pre-defined criteria. Fever reactions in ACWY + MMRV and MMRV groups were comparable. ACWY-TT can be co-administered with MMRV without affecting immunogenicity or safety profiles of either vaccine. This study has been registered at www.clinicaltrials.gov NCT00474266.