Produção Nacional
Revisado por pares
Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome
2008; Oxford University Press; Volume: 104; Issue: 5 Linguagem: Inglês
10.1111/j.1365-2672.2007.03707.x
ISSN1365-2672
AutoresRaquel Oliveira dos Santos Fontenelle, Selene Maia de Morais, Érika Helena Salles de Brito, Raimunda Sâmia Nogueira Brilhante, Rossana de Aguiar Cordeiro, Nilberto Robson Falcão do Nascimento, Marta Regina Kerntopf, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha,
Tópico(s)Bioactive Natural Diterpenoids Research
ResumoTo find new antifungal agents among essential oils from Brazilian Croton species.Plant leaves were steam distilled and the obtained essential oils were analyzed by gas chromatography/mass spectroscopy. The main constituents were estragole and anethole for Croton zehntneri, methyl-eugenol and bicyclogermacrene for Croton nepetaefolius and spathulenol and bicyclogermacrene for Croton argyrophylloides. The antifungal activity of essential oils was evaluated against Candida albicans, Candida tropicalis and Microsporum canis by the agar-well diffusion method and the minimum inhibitory concentration (MIC) by the broth microdilution method. Essential oils of Croton species demonstrated better activity against M. canis. Among the three plants C. argyrophylloides showed the best results, with MIC ranging from 9 to 19 microg ml(-1). The acute administration of the essential oil up to 3 g kg(-1) by the oral route to mice was devoid of overt toxicity.The studied essential oils are active in vitro against the dermatophyte M. canis and present relative lack of acute toxicity in vivo.Because of its antifungal activity and low toxicity, the essential oils of studied Croton species are promising sources for new phytotherapeutic agents to treat dermatophytosis.
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