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Early-onset rhabdomyolysis related to daptomycin use

2007; Elsevier BV; Volume: 30; Issue: 5 Linguagem: Inglês

10.1016/j.ijantimicag.2007.07.009

1872-7913

Samir J. Patel, Tobias C. Samo, Wadi N. Suki,

Drug-Induced Adverse Reactions

Rhabdomyolysis is a well-documented side effect of daptomycin and is associated with hyperuricemia. However, the occurrence of acute gouty arthritis secondary to rhabdomyolysis-induced hyperuricemia has not been reported. We report a case of a patient who presented with daptomycin-induced rhabdomyolysis prior to the usual 7-10-day administration period. This case was complicated with acute gouty arthritis after 7 days from the onset of rhabdomyolysis symptoms. Treatment consisted of fluid management with the addition of prednisone for gouty arthritis treatment given his poor kidney function. This report indicates the importance of early monitoring of creatine kinase levels in patients on daptomycin to prevent complications from rhabdomyolysis.