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The effect of a toothpaste containing 2% zinc citrate and 0.3% Triclosan on bacterial viability and plaque growth in vivo compared to a toothpaste containing 0.3% Triclosan and 2% copolymer

2003; Elsevier BV; Volume: 53; Issue: 6 Linguagem: Inglês

10.1111/j.1875-595x.2003.tb00916.x

1875-595X

S.E. Adams, Allister J. Theobald, Nathan Jones, M.G. Brading, Trevor F. Cox, Asunción Méndez, D.M. Chesters, David Gillam, Claire Hall, J.S. Holt,

HIV/AIDS oral health manifestations

Objective: To compare the antimicrobial efficacy and effect on plaque growth of a new silica-based fluoride toothpaste containing 2% zinc citrate/0.3% Triclosan with a silica-based fluoride toothpaste containing 0.3% Triclosan/2% copolymer. Methods: In Study 1, plaque was collected after one week's use of each toothpaste and assessed for bacterial viability, live/dead ratio and microbial membrane integrity. In study 2, plaque was measured immediately and 18 hours after a single brushing with the specified toothpastes. Results: The 2% zinc citrate/0.3% Triclosan formulation significantly reduced the total number of viable aerobic and anaerobic bacteria (p=0.0223 and p=0.0443 respectively) compared to the 0.3% Triclosan/2% copolymer formulation. Both toothpastes increased the bacterial membrane permeability significantly. However, the proportion of live bacteria for the 2% zinc citrate/0.3% Triclosan product was significantly reduced (p<0.05). Study 2 showed significantly less plaque growth 18 hours after using the 2% zinc citrate/0.3% Triclosan toothpaste compared to the 0.3% Triclosan/2% copolymer toothpaste (p<0.01). Conclusion: Regular use of a fluoride toothpaste containing 2% zinc citrate and 0.3% Triclosan, significantly reduced the viability of plaque bacteria compared to a fluoride toothpaste containing 0.3% Triclosan/ 2% copolymer 12 hours after brushing. In addition, a clinical plaque growth study confirmed that this antimicrobial efficacy leads to a significant reduction in plaque growth.