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Dupuytren’s disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor

1998; British Editorial Society of Bone & Joint Surgery; Volume: 80-B; Issue: 5 Linguagem: Inglês

10.1302/0301-620x.80b5.0800907

2044-5377

J. W. Hutchinson, Gillian Tierney, S. L. Parsons, Tim Davis,

Orthopedic Surgery and Rehabilitation

In a series of 12 patients with inoperable gastric carcinoma who had treatment with a synthetic matrix metalloproteinase inhibitor (Marimastat) for more than one month, six developed a frozen shoulder or a condition resembling Dupuytren’s disease. This suggests that the matrix metalloproteinases, a family of naturally occurring proteinases, may be involved in the pathogenesis of these two conditions. Our observation opens avenues for further research which could lead to local or systemic therapeutic interventions for frozen shoulder and Dupuytren’s disease.