JunB Induced by Constitutive CD30–Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Signaling Activates the CD30 Promoter in Anaplastic Large Cell Lymphoma and Reed-Sternberg Cells of Hodgkin Lymphoma
2005; American Association for Cancer Research; Volume: 65; Issue: 17 Linguagem: Inglês
10.1158/0008-5472.can-05-0925
ISSN1538-7445
AutoresMariko Watanabe, Masataka Sasaki, Kinji Itoh, Masaaki Higashihara, Kazuo Umezawa, Marshall E. Kadin, Lawrence J. Abraham, Toshiki Watanabe, Ryouichi Horie,
Tópico(s)NF-κB Signaling Pathways
ResumoAbstract High expression of CD30 and JunB is characteristic of tumor cells in anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL). Possible interactions of CD30 and JunB were examined in this study. We found that the CD30 promoter in tumor cells of both nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)–positive and NPM-ALK-negative ALCL and HL is regulated by a constitutively active CD30–extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK). Phosphorylation of ERK1/2 MAPK was confirmed in nuclei of tumor cells in both ALCL and HL. CD30-ERK1/2 MAPK signals induce JunB expression, which maintains high activity of the CD30 promoter. JunB induction seems to be largely independent of nuclear factor κB in ALCL and HL. These results show a common mechanism of CD30 overexpression in ALCL and HL, although the outcome of CD30 signaling differs between NPM-ALK-positive ALCL and NPM-ALK-negative ALCL, cutaneous ALCL, and HL as we recently reported.
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