Portal de Periódicos da CAPES

Nosocomial Bacteremia Caused by Antibiotic‐Resistant Gram‐Negative Bacteria in Critically Ill Patients: Clinical Outcome and Length of Hospitalization

2002; Oxford University Press; Volume: 34; Issue: 12 Linguagem: Inglês

10.1086/340616

1537-6591

Stijn Blot, Koenraad Vandewoude, Dirk De Bacquer, Francis Colardyn,

Antibiotic Use and Resistance

Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; n = 120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer hospitalization before the onset of the bacteremia. The in-hospital mortality for patients with bacteremia caused by AB-S strains was 41.8%; for patients infected with AB-R strains, it was 45.0% (P = .576). A multivariate survival analysis demonstrated that older age (P = .009), a high-risk source of bacteremia (abdominal and lower respiratory tract; P = .031), and a high acute physiology and chronic health evaluation II-related expected mortality (P = .032) were independently associated with in-hospital mortality (P < .05). Antibiotic resistance in nosocomial bacteremia caused by gram-negative bacteria does not adversely affect the outcome for critically ill patients.