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Bronchopulmonary infection–colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study

2015; Elsevier BV; Volume: 15; Issue: 3 Linguagem: Inglês

10.1016/j.jcf.2015.09.004

1873-5010

Juan de Dios Caballero, Rosa del Campo, Ana Royuela, Amparó Solé, Luís Máiz, Casilda Olveira, Esther Quintana‐Gallego, Javier de Gracia, Marta Cobo, Elia Gómez G. de la Pedrosa, Antonio Oliver, Rafael Cantón, Amparó Solé, Isidoro Cortell, Òscar Asensio, Gloria García, María Teresa Martínez, María Cols, Antonio Salcedo, Carlos Vázquez, F. Baranda, Rosa Girón, Eduard Quintana, Isabel Delgado, María Ángeles de Miguel, Marta García, Concepción Oliva, María Concepción Prados, María Isabel Barrio, María Dolores Pastor‐Vivero, Casilda Olveira, Javier de Gracia, Antonio Álvarez, Amparo Escribano, Silvia Castillo, Joan Figuerola, Bernat Togores, Antonio Oliver, Carla López-Causapé, Juan de Dios Caballero, Marta Tato, Luís Máiz, Lucrecia Suárez, Rafael Cantón,

Pneumonia and Respiratory Infections

BackgroundClinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.Methods24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.Results341 patients [mean (SD) age 21 (11) years, 180 ≥ 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p < 0.001 and p = 0.003, respectively).ConclusionsThe representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.