Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
2007; Royal Society of Chemistry; Volume: 5; Issue: 10 Linguagem: Inglês
10.1039/b703033a
ISSN1477-0539
AutoresChristopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith, Russell A. Lewthwaite, Steven V. Ley,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.
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