Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum( ii ) and rhenium( i ) with a ligand targeting the translocator protein (TSPO)

Artigo Revisado por pares

Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum( ii ) and rhenium( i ) with a ligand targeting the translocator protein (TSPO)

2014; Royal Society of Chemistry; Volume: 43; Issue: 43 Linguagem: Inglês

10.1039/c4dt01540a

ISSN

1477-9234

Autores

Nicola Margiotta, Nunzio Denora, Sara Piccinonna, Valentino Laquintana, Francesco M. Lasorsa, Massimo Franco, Giovanni Natile,

Tópico(s)

Lanthanide and Transition Metal Complexes

Resumo

The 18 kDa translocator protein (TSPO) is overexpressed in many cancers and is also abundant in activated microglial cells occurring in neurodegenerative diseases.

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Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum( ii ) and rhenium( i ) with a ligand targeting the translocator protein (TSPO)