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The carcinoembryonic antigen and its prognostic impact on immunocytologically detected intraperitoneal colorectal cancer cells

2001; Elsevier BV; Volume: 181; Issue: 2 Linguagem: Inglês

10.1016/s0002-9610(00)00555-9

1879-1883

Ilka Vogel, H. Francksen, Edlyn Soeth, Doris Henne‐Bruns, Bernd Kremer, Hartmut Juhl,

Galectins and Cancer Biology

Carcinoembryonic antigen (CEA) has been suggested to promote colon cancer progression. In this study we analyzed the prognostic impact of CEA expression on intraperitoneally detected single colon cancer cells.Peritoneal lavage samples of 135 colorectal cancer patients were immunocytologically analyzed, including a staining of cellular CEA; serum CEA levels were measured; and 5-year survival rates were calculated according to immunocytological findings and CEA expression.The worst survival rate of 20% was found in patients suffering from CEA-expressing intraperitoneal tumor cells (P = 0.0006). The prognostic impact of an intraperitoneal tumor cell finding significantly increased when serum CEA levels were elevated: only 23% survived 5 years in contrast to a 85% 5-year survival rate of patients who neither had signs of dissemination nor showed elevated serum CEA values (P = 0.0010).This study shows that the determination of CEA expression improves the prognostic impact of an intraperitoneal tumor cell finding.