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Recognition of Risk for Clinically Significant Drug Interactions among HIV‐Infected Patients Receiving Antiretroviral Therapy

2010; Oxford University Press; Volume: 50; Issue: 10 Linguagem: Inglês

10.1086/652149

1537-6591

John G. Evans‐Jones, Lucy E. Cottle, David Back, Sara Gibbons, Nicholas J. Beeching, Peter B. Carey, Saye Khoo,

Medication Adherence and Compliance

We assessed the risk of clinically significant drug interactions in patients receiving antiretrovirals, and their recognition by physicians. Clinically significant drug interactions were recorded in 27% of 159 patients, with 15% of interactions potentially lowering antiretroviral concentrations. Risk of clinically significant drug interactions was significantly related to receipt of protease inhibitors. Only 36% of clinically significant drug interactions were correctly identified by physicians.