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BIBTEX RIS

Palladium‐Catalyzed Insertion of α‐Diazoesters into Vinyl Halides To Generate α,β‐Unsaturated γ‐Amino Esters

2009; Wiley; Volume: 48; Issue: 20 Linguagem: Inglês

10.1002/anie.200805483

ISSN

1521-3773

Autores

Romas Kudirka, Sean K. J. Devine, Christopher S. Adams, David L. Van Vranken,

Tópico(s)

Catalytic Cross-Coupling Reactions

Resumo

As easy as 1, 2, 3: A palladium-catalyzed three-component coupling generates alpha,beta-unsaturated gamma-amino acids in a single step (see scheme). The reaction is believed to involve migration of a vinyl substituent to a highly electrophilic palladium carbene. Unlike previous synthetic approaches, this synthesis provides access to gamma-amino acids with non-natural side chains.

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