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Alcohol drinking and bladder cancer risk: a meta-analysis

2011; Elsevier BV; Volume: 23; Issue: 6 Linguagem: Inglês

10.1093/annonc/mdr460

1569-8041

Claudio Pelucchi, Carlotta Galeone, Irene Tramacere, Vincenzo Bagnardi, Eva Negri, Farhad Islami, Lorenza Scotti, Rino Bellocco, Giovanni Corrao, Paolo Boffetta, Carlo La Vecchia,

Urinary and Genital Oncology Studies

We aimed at investigating the risk of bladder cancer at different levels of alcohol consumption by conducting a meta-analysis of epidemiological studies.In October 2010, we carried out a systematic literature search in the Medline database, using PubMed. We identified 16 case-control and 3 cohort studies, including a total of 11 219 cases of bladder cancer, satisfying the inclusion criteria for this meta-analysis. Moderate alcohol intake was defined as <3 drinks per day (i.e. <37.5 g of ethanol per day) and heavy intake as ≥3 drinks/day. Pooled estimates of the relative risks (RR) and the corresponding 95% confidence intervals (CI) were calculated using random effects models.Compared with non-drinkers, the pooled RRs of bladder cancer were 1.00 (95% CI 0.92-1.09) for moderate and 1.02 (95% CI 0.78-1.33) for heavy alcohol drinkers. When we excluded four studies that did not adjust for tobacco smoking, the corresponding estimates were 0.98 (95% CI 0.89-1.07) and 0.97 (95% CI 0.72-1.31).This meta-analysis of epidemiological studies provides definite evidence on the absence of any material association between alcohol drinking and bladder cancer risk, even at high levels of consumption.