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Reversible pH‐Regulated Control of Photosensitized Singlet Oxygen Production Using a DNA i‐Motif

2010; Wiley; Volume: 49; Issue: 43 Linguagem: Inglês

10.1002/anie.201003612

1521-3773

Thomas Tørring, Rasmus Toftegaard, Jacob Arnbjerg, Peter R. Ogilby, Kurt V. Gothelf,

Nanoplatforms for cancer theranostics

On again, off again: Reversible pH-controlled on-and-off switching of a singlet oxygen sensitizer is achieved when an i-motif DNA sequence is employed to control the proximity of a singlet oxygen sensitizer and a quencher (see picture). At pH values less than 5, the i-motif is stable and the singlet oxygen sensitizer quenched, whereas at pH values above 8 the i-motif is denatured and singlet oxygen production is increased by a factor of 35. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.