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Synthesis of a New Unnatural Amino Acid with a Benzodiazepine‐Containing Side Chain and Incorporation into a Tripeptide

1994; Wiley; Volume: 33; Issue: 17 Linguagem: Inglês

10.1002/anie.199417371

1521-3773

Johann Mulzer, Fridtjof Schröder, Alessandro Lobbia, J. Buschmann, Peter Luger,

Biopolymer Synthesis and Applications

Peptidomimetics based on benzodiazepines can be made from nonnatural amino acids such as 1. They can function both as peptidic and nonpeptidic receptor ligands, owing to the modified amino acid side chains. Compound 1 was synthesized from monomethyl L-glutamate in seven steps in 15% overall yield.