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Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis

2008; Oxford University Press; Volume: 47; Issue: 5 Linguagem: Inglês

10.1093/rheumatology/ken024

1462-0332

Bernat Galarraga, M. Ho, Hamdy M. Youssef, Andrew G. Hill, H. McMahon, Cindy Hall, S. Ogston, G. Nuki, J. J. F. Belch,

Inflammatory mediators and NSAID effects

Objectives. Dose-dependant gastrointestinal and cardiovascular side-effects limit the use of NSAIDs in the management of RA. The n-3 essential fatty acids (EFAs) have previously demonstrated some anti-inflammatory and NSAID-sparing properties. The objective of this study was to determine whether cod liver oil supplementation helps reduce daily NSAID requirement of patients with RA.