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The Genome Sequence of Drosophila melanogaster

2000; American Association for the Advancement of Science; Volume: 287; Issue: 5461 Linguagem: Inglês

10.1126/science.287.5461.2185

1095-9203

Mark D. Adams, S Celniker, Robert A. Holt, Cheryl Evans, Jeannine D. Gocayne, Peter G. Amanatides, Steven E. Scherer, Peter W. Li, Roger A. Hoskins, Richard F. Galle, Reed George, Suzanna Lewis, Stephen M. Richards, Michael Ashburner, Scott N. Henderson, Granger G. Sutton, Jennifer R. Wortman, Mark Yandell, Qing Zhang, Lin X. Chen, Rhonda Brandon, Yu-Hui C. Rogers, Robert G. Blazej, Mark Champe, Barret D. Pfeiffer, Kenneth H. Wan, Clare Doyle, Evan G. Baxter, Gregg Helt, Catherine R. Nelson, George L. Gabor, Miklós, Josep F. Abril, Anna Agbayani, Hui-Jin An, Cynthia Andrews‐Pfannkoch, Danita Baldwin, Richard M. Ballew, Anand Basu, James Baxendale, Leyla Bayraktaroglu, Ellen M. Beasley, Karen Beeson, Panayiotis V. Benos, Benjamin P. Berman, Deepali Bhandari, Slava Bolshakov, Dana Borkova, Michael R. Botchan, John Bouck, Peter Brokstein, Phillipe Brottier, Kenneth C. Burtis, Dana Busam, H. Butler, Édouard Cadieu, Angela Center, Ishwar Chandra, J. Michael Cherry, Simon Cawley, Carl Dahlke, Lionel B. Davenport, Peter L. Davies, Beatriz de Pablos, Arthur L. Delcher, Zuoming Deng, Anne Deslattes Mays, Ian Dew, Suzanne M. Dietz, Kristina Dodson, Lisa Doup, Michael Downes, Shannon Dugan-Rocha, Boris C. Dunkov, Patrick Dunn, Kenneth J. Durbin, Carlos Evangelista, Concepción Ferraz, Steven Ferriera, Wolfgang Fleischmann, Carl Fosler, Andrei Gabrielian, Neha Garg, William M Gelbart, Ken Glasser, Anna Glodek, Fangcheng Gong, James H. Gorrell, Zhiping Gu, Ping Guan, Michael A. Harris, Nomi L. Harris, Damon A. Harvey, Thomas J. Heiman, Judith Hernandez, Jarrett Houck, Damon Hostin, Kathryn A. Houston, Timothy J. Howland, Minghui Wei, Chinyere Ibegwam, Mena Jalali, Francis Kalush, Gary H. Karpen, Zhaoxi Ke, James A. Kennison, Karen A. Ketchum, Bruce E. Kimmel, Chinnappa D. Kodira, Cheryl Kraft, Saul Kravitz, David Kulp, Zhongwu Lai, Paul Lasko, Yiding Lei, Alexander A. Levitsky, Jiayin Li, Zhenya Li, Yong Liang, Xiaoying Lin, Xiangjun Liu, Bettina Mattei, Tina C. McIntosh, Michael P. McLeod, D McPherson, Gennady V. Merkulov, Natalia V. Milshina, Clark Mobarry, Joe Morris, Ali Moshrefi, Stephen M. Mount, Mee Moy, Brian J. Murphy, Lee Murphy, Donna M. Muzny, David L. Nelson, David R. Nelson, Keith A. Nelson, Katherine Nixon, Deborah Nusskern, Joanne Pacleb, Michael Palazzolo, Gjange S. Pittman, Sue Pan, John R. Pollard, Vinita Puri, Martin G. Reese, Knut Reinert, Karin Remington, Robert D. C. Saunders, Frederick Scheeler, Hua Shen, Bixiang Christopher Shue, Inga Sidén‐Kiamos, Michael A. Simpson, Marian Skupski, Tom Smith, Eugene G. Spier, Allan C. Spradling, Mark Stapleton, Renee Strong, Eric I. Sun, Robert Svirskas, Cyndee Tector, Russell Turner, Eli Venter, Aihui H. Wang, Xin Wang, Zhenyuan Wang, David A. Wassarman, George M. Weinstock, Jean Weissenbach, Sherita M. Williams, Trevor Woodage, Kim C. Worley, David Wu, Song Yang, Qingping Yao, Jane J. Ye, Ru‐Fang Yeh, Jayshree Zaveri, Ming Zhan, Guangren Zhang, Qi Zhao, Liansheng Zheng, Xiangqun Zheng-Bradley, Fei Zhong, Wenyan Zhong, Xiaojun Zhou, Shiaoping C. Zhu, Zhu Xiao-hong, Hamilton O. Smith, Richard A. Gibbs, Eugene W. Myers, Gerald M. Rubin, J. Craig Venter,

Chromosomal and Genetic Variations

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.