The spectrum of disease in chronic traumatic encephalopathy
2012; Oxford University Press; Volume: 136; Issue: 1 Linguagem: Inglês
10.1093/brain/aws307
ISSN1460-2156
AutoresAnn C. McKee, Thor D. Stein, Christopher J. Nowinski, Robert A. Stern, Daniel H. Daneshvar, Victor E. Alvarez, Hyo-Soon Lee, Garth F. Hall, Sydney M. Wojtowicz, Christine M. Baugh, David Riley, Caroline A. Kubilus, Kerry A. Cormier, Matthew A. Jacobs, Brett Martin, Carmela R. Abraham, Tsuneya Ikezu, R. Ross Reichard, Benjamin Wolozin, Andrew E. Budson, Lee E. Goldstein, Neil W. Kowall, Robert C. Cantu,
Tópico(s)Alzheimer's disease research and treatments
ResumoChronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury.We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging in age from 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% of whom were also athletes) and one individual who engaged in self-injurious head banging behaviour.Eighteen age-and gender-matched individuals without a history of repetitive mild traumatic brain injury served as control subjects.In chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages I-IV.Multifocal axonal varicosities and axonal loss were found in deep cortex and subcortical white
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