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Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia

1998; American Society for Microbiology; Volume: 42; Issue: 6 Linguagem: Inglês

10.1128/aac.42.6.1488

1098-6596

Theodore E. Nash, William G. Rice,

Parasitic infections in humans and animals

ABSTRACT Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 μM or less inhibited the growth of Giardia lamblia . The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 μM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.