Neural induction: old problem, new findings, yet more questions
2005; The Company of Biologists; Volume: 132; Issue: 9 Linguagem: Inglês
10.1242/dev.01794
ISSN1477-9129
Autores Tópico(s)Animal Genetics and Reproduction
ResumoDuring neural induction, the embryonic neural plate is specified and set aside from other parts of the ectoderm. A popular molecular explanation is the`default model' of neural induction, which proposes that ectodermal cells give rise to neural plate if they receive no signals at all, while BMP activity directs them to become epidermis. However, neural induction now appears to be more complex than once thought, and can no longer be fully explained by the default model alone. This review summarizes neural induction events in different species and highlights some unanswered questions about this important developmental process.
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