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The Relationships of Adiponectin with Insulin and Lipids Are Strengthened with Increasing Adiposity

2005; Oxford University Press; Volume: 90; Issue: 7 Linguagem: Inglês

10.1210/jc.2005-0019

1945-7197

Lisa J. Martin, Jessica G. Woo, Stephen R. Daniels, Elizabeth Goodman, Lawrence M. Dolan,

Adipose Tissue and Metabolism

Context: Adipose tissue inflammation has been implicated in the pathogenesis of obesity-related comorbidities. Adiponectin, an antiinflammatory protein, improves insulin sensitivity and lipid levels systemically. Because adiponectin is secreted by adipocytes, it may also act locally to counteract insulin resistance and dyslipidemia worsened by inflammation.