Survival Benefit of Post-mastectomy Radiotherapy in Breast Carcinoma Patients with T1-2 Tumor and 1-3 Axillary Lymph Node(s) Metastasis
2012; Oxford University Press; Volume: 42; Issue: 7 Linguagem: Inglês
10.1093/jjco/hys052
ISSN1465-3621
AutoresNüvi̇t Duraker, Davut Demir, Bedia Batı, Burak Yılmaz, Y. Bati, Zeynep Civelek Çaynak, Erman Sobutay,
Tópico(s)Advanced Breast Cancer Therapies
ResumoTo investigate the role of post-mastectomy radiotherapy in breast carcinoma patients with a tumor size of 5 cm or smaller (T1-2) and 1-3 axillary lymph node(s) metastasis (N1).We retrospectively reviewed the file records of 575 patients receiving radiotherapy (452 patients) and not receiving radiotherapy (123 patients).In the whole series, locoregional recurrence-free survival was significantly better in patients receiving radiotherapy compared with patients not receiving radiotherapy (P<0.001); in the multivariate Cox analysis, radiotherapy had an independent prognostic value (P 0.25 and in T2N1 breast carcinoma patients with a lymph node ratio of >0.08. In patients with a lymph node ratio equal to or less than these ratios, post-mastectomy radiotherapy could be omitted to avoid radiotherapy-related risks.
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